One observes regulation at every biological level. Organisms, cells, and biochemical processes operate efficiently, normally wasting neither material nor energy, and adjusting their functions to external influences. Nature evidently has evolved mechanisms specifically dedicated to regulation at many levels. What is the molecular basis of this control?In the 1950s these molecular control mechanisms began to be explored seriously. The discoveries of feedback inhibition of enzyme activity were important because they gave an initial example of how regulation is achieved at the (...) molecular level. We showed that certain enzymes are composed of two parts, one for catalysis and another distinct part present only to regulate this catalysis. Catalytic activity can be either stimulated or inhibited when a small molecule in the environment combines with the enzyme's regulatory site. In particular, a final product of a metabolic pathway generates a feedback loop which automatically limits its own excessive production, by combining with the regulatory site of an early enzyme in that pathway. Later studies showed that catalytic and regulatory structures of some enzymes could be separated physically.The discovery of regulatory sites and their interaction with molecules unrelated to their substrates was the basis for the generalized allosteric concept. This concept extends the regulatory site idea to a wide variety of processes such as control of gene expression, hormone action, and cellular growth. (shrink)

The Pajama (Pardee, Jacob, Monod) experiment provided a breakthrough in our understanding of the molecular mechanisms by which gene expression is regulated. Today, twenty‐five years later it provides a paradigm for thinking about problems of gene expression, such as growth regulation and differentiation. From this experiment emerged entities such as repressors, regulatory genes, the operon as a group of jointly controlled genes, and messenger RNA.

The computational paradigm, which has dominated psychology and artificial intelligence since the cognitive revolution, has been a source of intense debate. Recently, several cognitive scientists have argued against this paradigm, not by objecting to computation, but rather by objecting to the notion of representation. Our analysis of these objections reveals that it is not the notion of representation per se that is causing the problem, but rather specific properties of representations as they are used in various psychological theories. Our analysis (...) suggests that all theorists accept the idea that cognitive processing involves internal information-carrying states that mediate cognitive processing. These mediating states are a superordinate category of representations. We discuss five properties that can be added to mediating states and examine their importance in various cognitive models. Finally, three methodological lessons are drawn from our analysis and discussion. (shrink)

Pickering & Garrod (P&G) suggest that communicators synchronize their processing at a number of linguistic levels. Whereas their explanation suggests that representations are being compared across individuals, there must be some representation of all conversation participants in each participant's head. At the level of the situation model, it is important to maintain separate representations for each participant. At other levels, it seems less crucial to have a separate representation for each participant. This analysis suggests that different mechanisms may synchronize representations (...) at different linguistic levels. (shrink)

Machery argues that concepts are too heterogeneous to be a natural kind. I argue that the book does not go far enough. Theories of concepts assume that the task of categorizing warrants a unique set of cognitive constructs. Instead, cognitive science must look across tasks to find a fundamental set of cognitive mechanisms.

This essay argues that the affective component inherent in the enthymeme is the essence of aristotle's concept of the enthymeme as practical reasoning. 'affective component' refers to emotions and feelings. The three proofs of the thesis are the etymology of 'enthymeme', Aristotle's works on human action and practical wisdom, And aristotle's rhetoric. These sources show the inherent relation between enthymemes and phronesis, Or practical reasoning, Not nous, Or abstract intellect.

The proposed model is put forward as a template for the dynamical systems approach to embodied cognition. In order to extend this view to cognitive processing in general, however, two limitations must be overcome. First, it must be demonstrated that sensorimotor coordination of the type evident in the A-not-B error is typical of other aspects of cognition. Second, the explanatory utility of dynamical systems models must be clarified.

Pothos suggests dispensing with the distinction between rules and similarity, without defining what is meant by either term. We agree that there are problems with the distinction between rules and similarity, but believe these will be solved only by exploring the representations and processes underlying cases purported to involve rules and similarity.

Although, when first introduced, Copernicus's theory considered as a whole was not superior to the Ptolemaic theory according to any of the usual criteria for comparing theories and determining their acceptability, it did have features which provided the early Copernicans with good reasons for entertaining it and trying to develop it further. These features are discussed and then three plausibility considerations which seem to be operative in this case are formulated.

Representation is a central part of models in cognitive science, but recently this idea has come under attack. Researchers advocating perceptual symbol systems, situated action, embodied cognition, and dynamical systems have argued against central assumptions of the classical representational approach to mind. We review the core assumptions of the dominant view of representation and the four suggested alternatives. We argue that representation should remain a core part of cognitive science, but that the insights from these alternative approaches must be incorporated (...) into models of cognitive processing. (shrink)

Different aspects of people's interactions with money are best conceptualized using the drug and tool theories. The key question is when these models of money are most likely to guide behavior. We suggest that the Drug Theory characterizes motivationally active uses of money and that the Tool Theory characterizes behavior in motivationally cool situations. (Published Online April 5 2006).

Man's belief in God is often contrasted with man's disbelief, Atheism; but the nature of human belief is contrastable with the nature of the belief of demons. A point of contrast lies in the consequences of the different sort of reasons men and demons must be understood to have. One consequence has to do with the vision of the world, seeing the world as God's creation, which men are expected to achieve and demons are not. The logic of the ?seeing (...) as? formula is explored and found wanting even though it seems inescapable in connection with human belief. In the end human belief appears more peculiar than demonic. (shrink)

The target article suggests that many practices of experimental economists are preferable to those used by psychologists studying judgment and decision making. The advantages of the psychological approach become clear when the focus of research shifts from choice output to choice processes. I illustrate this point with an example from research on similarity comparisons.

The causal theory of action had suffered from inattention or linguistically motivated rejection until it was revived in 1963 by Donald Davidson. Since then the causal theory has had a continuing acceptance without having had an inspection of its assumptions. There are reasons to suspect that the theory is as unfounded as it is undoubted. Those reasons are reviewed here which have to do with the definitive moment when states such as beliefs and desires must change character to become causal (...) events. (shrink)

It is tempting to explicate the mastery of language, as many philosophers have, with how we come to learn language. Interpreting how we come to learn a language necessarily involves saying what the mind's relevant capacities are. Too long we have been told that those capacities are adaptive to, as well as within, a social context; it seemed plausible to argue that we learn to have (propositional) thoughts as we learn and use the language conatively. This essay tries to persuade (...) the reader that there is something else besides, something that cannot be taught. That something, elusive as it is, is caught in one of the phrases with which the OED defines passion , 'An eager outreaching of the mind towards something'. Passion understood in this way is conceptually indispensable to human language. (shrink)

Each contributor to this book has used personal experience as the basis from which to frame his individual sociological perspectives. Because they have personalized their work, their accounts are real, and recognizable as having come from 'real' persons, about 'real' experiences. There are no objectively-distanced disembodied third person entities in these accounts. These writers are actual people whose stories will make you laugh, cry, think, and want to know more.

Twenty-four capitals of Nazi-occupied countries suffered grievously under the jackboot heel of the Third Reich. In one capital, however, the situation was truly bizarre, and it takes an artful work...

This paper is a detailed critical study of Adolf Grünbaum's work on the Duhemian thesis. I show that (a) Grünbaum's geometrical counterexample to the (D1) subthesis is unsuccessful, even with minimal claims made for what the counterexample is supposed to show, and (b) the (D2) subthesis is not a reasonable one (and cannot correctly be attributed to Duhem). The paper concludes with an argument about the relation between the Duhemian thesis, concerning component hypotheses of a scientific theory, and the view (...) that it is impossible to falsify entire theories conclusively. (shrink)

Across America, especially in the aftermath of 9/11, parents rely on K12 schooling to prepare their children for the shocks, the perils, and especially the bright possibilities that are part of our warp-speed future. A new generation of school staffers is forging a fresh learning partnership with youngsters for whom creative computer-based schooling is as natural as breathing.

The European Legacy, Volume 17, Issue 4, Page 561-562, July 2012.

It seems to have been taken for granted that we all know what a human action is. However in attempting to draw from what philosophers have said about actions the necessary clues as to their distinguishing features, one finds little to discourage the idea that there is no way of distinguishing one category of occurrences, human actions, from the complex of different sorts of things which happen. From this I am tempted to conclude that there is no category of human (...) action. But before drawing such a conclusion an ancient but terrible question must be faced: What sorts of things happen in the world ? This ancient question is faced but not answered. It is brought up because the failure to find a satisfactory answer to the question, Is human action a category? is a failure even to find a satisfactory assumption about what kind of reference the term ?human action? is supposed to have. (shrink)

From 1945 to date Holocaust research has concentrated on complex matters such as militant Jewish resistance, convoluted Nazi strategies, ambivalent bystander behavior, controversial ghetto leadersh...